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KMID : 0390219990100010053
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Journal of Clinical Otolaryngology, Head and Neck Surgery
1999 Volume.10 No. 1 p.53 ~ p.60
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Expression of IL-4, IL-6, GM-CSF and IFN-γmRNAs in Nasal Polyps
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Abstract
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Background and Objectives : Nasal polyps are chronic inflammatory polyps originating
from the middle meatus and maxillary sinus, and are usually resistant to medical
treatment and often recur after surgical resections. Although the etiology and the
pathogenesis are still unknown, recent studies have suggested an immunologic role for
the development of nasal polyps. This study aimed to investigate the cellular infiltration
and cytokine mRNA expression in nasal polyps, and compare the histopathology and
cytokine profile of patients with clinically different nasal polyps. Materials and Methods :
Authors examined the infiltration of lymphocytes, eosinophils, and plasma cells as well
as the expression of IL-4, IL-6, IFN-γ, and GM-CSF mRNAs using the
semiquantitative RT-PCR method in antrochoanal(n=6), allergic nasal(n=6), and
nonallergic nasal polyps(n=16), and the middle turbinate of normal controls(n=4). Results
: Plasma cell infiltration was more intense in nasal polyps irrespective of the type
(p<0.05). and eosinophil infiltration in allergic nasal polyps was more intense than in the
normal tissue (p<0.05). Antrochoanal polyps showed higher levels of IL-4, IL-6, and
GM-CSF mRNA expression, and increased IL-4/IFN-γratio, suggesting that the
humoral immune reaction was predominant. Nonallergic nasal polyps showed higher
levels of IFN-γ, and GM-CSF mRNA expression, and low IL-4/IFN-γratio,
suggesting that the cellular immune reaction was predominant. Allergic nasal polyps
showed higher levels of IL-4, IFN-γ, and GM-CSF mRNA expression, suggesting that
both the cellular and humoral immune reactions may coexist. Conclusion : Different
immune mechanisms may be responsible for nasal polyps of different clinical types.
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KEYWORD
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